Folate-responsive birth defects: of mice and womens
نویسندگان
چکیده
منابع مشابه
Folate-responsive birth defects: of mice and women.
The recognition that periconceptional folate supplementation in addition to normal dietary folate intake reduced the incidence of neural tube defects (NTDs), one of the most common birth defects, has led to mandatory folate fortification in the United States and ;50 other countries (1, 2). Fortification programs have reduced the incidence of NTDs by ;20–80%, with the largest reductions occurrin...
متن کاملShmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice.
BACKGROUND Folic acid supplementation prevents the occurrence and recurrence of neural tube defects (NTDs), but the causal metabolic pathways underlying folic acid-responsive NTDs have not been established. Serine hydroxymethyltransferase (SHMT1) partitions folate-derived one-carbon units to thymidylate biosynthesis at the expense of cellular methylation, and therefore SHMT1-deficient mice are ...
متن کاملCrooked tail (Cd) models human folate-responsive neural tube defects.
Genetic correlation of human neural tube defects (NTDs) with NTD genes identified in mouse may unravel predisposing complex traits for assessment of individual risk and treatment in clinical settings. Folic acid (FA) can reduce the recurrence of NTDs in human populations by as much as 50-70%, though the mechanism of this rescue is unknown. We examined whether Crooked tail ( Cd ), a mouse strain...
متن کاملEffects of child birth preparation classes on parous womens’ attitude toward child birth
Background and Objectives: Pregnancy includes a temporary stress, and if not managed well, it becomes a prolonged problem which causes the mother and the family great distress. Some results show that training has a significant effect on reducing anxiety, pain and duration of labor. Mothers trained as compared with the control group experienced less pain and anxiety. This study aimed to investig...
متن کاملFolate and neural tube defects.
A protective effect of folate against the development of neural tube defects (NTDs), specifically, anencephaly and spina bifida, is now well recognized, having been established by a chain of clinical research studies over the past half century. This article summarizes the more important of these studies, which have led to the current situation in which all women capable of becoming pregnant are...
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ژورنال
عنوان ژورنال: The American Journal of Clinical Nutrition
سال: 2011
ISSN: 0002-9165,1938-3207
DOI: 10.3945/ajcn.111.029595